Elucidation of the function of Focal adherens junction in morphogenesis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K16145
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 44020:Developmental biology-related
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: Yamada Sohei 奈良先端科学技術大学院大学, 先端科学技術研究科, 特任助教 (40815528)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: ライブイメージング / フェムト秒レーザー / 力学測定

Outline of Final Research Achievements

The shape of tissues and organs is regulated by mechanical forces generated by the cell, including tension and pressure. However, the cellular force generation mechanism is not fully understood because of the lack of a system for force evaluation. In this study, we analyzed this question by focusing Focal Adherens Junctions (FAJs) in zebrafish development, and showed the possibility that FAJs are involved in force generation in the development.

Free Research Field

発生生物学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、形態形成過程において、新たな細胞間の力学的相互作用の制御メカニズムが存在する可能性を示しているため、その制御メカニズム多くの研究分野に大きなインパクトを与えることができると考えている。また、本研究の成果は、「細胞の生み出す力に着目した細胞集団の形態制御」技術開発への展開が期待される。