2020 Fiscal Year Final Research Report
Targeted neuronal control deep inside the mouse brain by near-infrared wavefront shaping
| Project/Area Number |
19K16188
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | 波面整形 / ホログラフィ / 光散乱 / 空間光変調 / 光遺伝学 |
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| Outline of Final Research Achievements |
In this study, we aimed to combine "guidestar-based optical wavefront shaping" and "the use of near-infrared light via upconversion nanoparticle (UNP)" towards optical focusing spot more than 2 mm deep in the mouse brain". In the first year, we completed the proof of principle experiment for the guidestar wavefront shaping, the preparation of scattering samples that mimic in-vivo mouse brains, the whole-cell patch clamp method. In the second year, we proposed and developed a high-speed one-dimensional spatial light modulator (1D-SLM) as a fundamental device to cope with the sub-millisecond scattering response changes shown by a live mouse brain. We will continue this research next year and challenge the final goal of generating the optical focusing spot in the deep brain of mice.
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| Free Research Field |
電子デバイス
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果である一次元空間光変調器は，最大25MHzのフレームレートを原理的に達成可能であり，このフレームレートは，これまでの世界記録から二桁以上の大幅な改善に相当する．この一次元空間光変調器は，本研究目的でもある「マウス脳深部での光スポット生成」を可能にするだけでなく，例えば，「大画面プロジェクタ」や「高速3D光スポット走査」，「スペクトル整形」，「光空間通信」など他分野へ応用展開できる．すなわち，一次元空間光変調器は，今後様々な分野に波及していくシーズ技術として大きく期待できる．
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