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2022 Fiscal Year Final Research Report

Verification of mutual compensation between genetic and epigenetic diversity

Research Project

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Project/Area Number 19K16201
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 45020:Evolutionary biology-related
Research InstitutionKitasato University

Principal Investigator

Katsumura Takafumi  北里大学, 医学部, 准教授 (10649544)

Project Period (FY) 2019-04-01 – 2023-03-31
KeywordsDNAメチル化 / 遺伝的多様性 / メダカ / 表現型可塑性
Outline of Final Research Achievements

Decreased genetic diversity can lead to extinction, but even low-genetic-diversity populations can generate offspring stably. This may be due to maintaining phenotypic diversity that can adapt to new environments through epigenetic changes. However, few studies have shown high epigenetic diversity in low-genetic-diversity populations. In this study, we examined genetic and epigenetic diversity in six wild medaka populations in Kagawa Prefecture to determine whether these types of diversity are interrelated. Seasonal variation in DNA methylation was greater in low-genetic-diversity populations, suggesting a weak negative correlation between genetic diversity and DNA methylation.

Free Research Field

進化生物学

Academic Significance and Societal Importance of the Research Achievements

近年,表現型に寄与するエピジェネティクスの実態とその効果が明らかになるにつれ,エピジェネティクスが突然変異だけでは説明できない表現型変化に関わっている可能性が示されている.DNA変化によらない表現型変化が,集団の生存や進化にどの程度寄与しているかを知ることは,生物進化を分子レベルで理解するために重要である.本研究により,エピジェネティック多様性が遺伝的多様性を互いに補償しうる可能性が示されたことから,適応進化におけるエピジェネティクスの役割の理解が進むだろう.さらに,環境が集団の生存や進化に重要であることも分子レベルで示唆され,持続可能な地球環境維持へのヒントとなることが期待される.

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Published: 2024-01-30  

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