2021 Fiscal Year Final Research Report
Analysis of a serotonergic modulation system of fly's courtship-induced behavior
Project/Area Number |
19K16257
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 46010:Neuroscience-general-related
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Research Institution | Hokkaido University (2020-2021) Nagoya University (2019) |
Principal Investigator |
Morimoto Nao 北海道大学, 遺伝子病制御研究所, 助教 (30762249)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | ショウジョウバエ / セロトニン / 持続行動 / 聴覚 / 求愛歌 / 神経科学 |
Outline of Final Research Achievements |
Animals receive much information from their surroundings, determine its value, and regulate the amount and the duration of their response behavior. However, the neural mechanisms involved have been largely unknown. In this research, based on my preliminary findings that serotonin is involved in the regulation of the amount and duration of response behavior, which is found using the fly auditory behavior, I succeeded in identifying the serotonergic neuron cluster and their modulating neurons. This has revealed one part of the serotonergic neural circuitry that regulates output behavior.
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Free Research Field |
神経科学
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Academic Significance and Societal Importance of the Research Achievements |
セロトニンによる神経伝達調節はショウジョウバエ以外にも動物で広く使われているため、本研究にて明らかになったセロトニンの役割は、神経科学一般に還元できるものであり、哺乳類におけるセロトニンの役割の理解にも貢献するものである。また、セロトニンが関連すると考えられる精神疾患も多く知られており、本研究は医学・創薬的な観点からも意義のあるものであると考えられる。
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