Towards understanding of novel molecular mechanisms regulating oligodendrocyte differentiation and myelination

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K16268
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 46010:Neuroscience-general-related
• Research Institution: Kindai University
• Principal Investigator: Ishino Yugo 近畿大学, 東洋医学研究所, 助教 (80625088)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: オリゴデンドロサイト / アルギニンメチル化 / PRMTs

Outline of Final Research Achievements

Protein arginine methylation has been recognized as one of key posttranslational modifications, which is mediated by protein arginine methyltransferases (PRMTs). Although arginine-methylated proteins are highly expressed in the brain, the expression and function of PRMTs have remained largely unknown. In this study, we revealed that CARM1, one of PRMTs, regulates proliferation, differentiation and myelination of oligodendrocytes during the early brain development.

Free Research Field

脳発達

Academic Significance and Societal Importance of the Research Achievements

本研究によってアルギニンメチル化酵素の1つであるCARM1が発達期オリゴデンドロサイトの分化・成熟に重要なことが始めて明らかとなった。オリゴデンドロサイトの機能制御を担う新たな遺伝子を見出したものであり、今後、脳内のアルギニンメチル化タンパク質の重要性を理解する上で重要な知見となる。