2020 Fiscal Year Annual Research Report
Positron emission tomography imaging of neuroinflammation
| Project/Area Number |
19K16274
|
|---|
| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
|---|
Principal Investigator |
Zhou Xiaoyun 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 博士研究員(任常) (40834099)
|
|---|
| Project Period (FY) |
2019-04-01 – 2021-03-31
|
| Keywords | PET / Neuroinflammation / CSF1R / P2X7R / MAGL |
|---|
| Outline of Annual Research Achievements |
The pharmacokinetics of 11C-GW2580, a novel tracer for CSF1 receptor (CSF1R) has been quantified and compared with that of a reported CSF1R radioligand, 11C-CPPC, in mice and monkeys. The study demonstrated that 11C-GW2580 enables in-vivo detection of microglial activation with higher sensitivity than 11C-CPPC. Furthermore, PET imaging of P2X7 receptor (P2X7R) revealed an age dependent increase of this receptor in a mouse model of tauopathy, and a positive correlation was found between the levels of P2X7R and TSPO, a commonly used biomarker for neuroinflammation. Collectively, our findings suggest the feasibility of P2X7R- and CSF1R-PET for imaging of reactive microglia in diverse neuroinflammatory diseases.
|
