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2020 Fiscal Year Final Research Report

Importance of lateral hypothalamic neurotensinergic neurons in wake maintenance

Research Project

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Project/Area Number 19K16296
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionTohoku Medical and Pharmaceutical University

Principal Investigator

Naganuma Fumito  東北医科薬科大学, 医学部, 助教 (80780519)

Project Period (FY) 2019-04-01 – 2021-03-31
Keywordsニューロテンシン / 視床下部 / 睡眠覚醒
Outline of Final Research Achievements

The optical stimulation of neurotensinergic neurons in lateral hypothalamus (Nts-LH) during NREM sleep strongly promoted arousal in mice. In addition, in vivo calcium imaging elucidated that neuronal activity of Nts-LH was high during wakefulness compared with during sleep. These results indicated that Nts-LH is important for wake maintenance.

Free Research Field

神経薬理学

Academic Significance and Societal Importance of the Research Achievements

Nts-LHが強力な覚醒作用を持つことは本研究により初めて明らかにされた。これに加え、Nts-LHは腹側被蓋核や結節乳頭核などの覚醒に重要なモノアミン神経系が神経核を有する脳部位に強く投射していることが明らかになっている。そのため、Nts-LHを中心とする覚醒調節機構の全容解明は、睡眠覚醒を司る神経基盤の理解に大きく貢献する可能性がある。将来的には睡眠障害の病態の理解や新規治療標的の開発につながることが期待される。

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Published: 2022-01-27  

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