the regulation of photo-induced reaction by synthetic polymer receptors

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K16342
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
• Research Institution: Kobe University
• Principal Investigator: Sunayama Hirobumi 神戸大学, 工学研究科, 特命准教授 (60706464)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 分子インプリンティング / 人工高分子レセプター / ポストインプリンティング修飾

Outline of Final Research Achievements

Construction of synthetic polymer-based reaction field prepared by molecularly imprinted polymers and the regulation of binding activity of molecularly imprinted polymers (MIP) by cavity-selective post-imprinting introduction of functional groups were proposed. MIP was prepared using a functional monomer bearing a benzamidine group, which can interact with carboxy group. Photo-dimerization reaction of 2-anthracene carboxylic acid with or without MIP was investigated and found that the reaction yield was changed by addition of MIP. It indicated that selective reaction field was created in MIP matrix. And also, regulation of binding activity of MIP was demonstrated by cavity-selective post-imprinting modification, which utilized the difference of binding affinity between the imprinted cavities.

Free Research Field

分子認識化学

Academic Significance and Societal Importance of the Research Achievements

生体内で行われる精緻で高効率な物質変換を産業応用することが望まれているが、応用できる例が限られることや、大量生産が困難等、非常にハードルが高い。テーラーメード分子認識材料作製法である分子インプリンティングに着目し、官能基の配置を巧みに制御することで反応収率を制御可能な本技術は、現在有機合成的に作製されるのが困難である医薬品や農薬等の分野の課題を解決する一つの足掛かりになる画期的な基盤的研究と位置付けられる。