2021 Fiscal Year Final Research Report
Elucidation of TLR activation mechanisms mediated by gangliosides and its acyl-chain structures
Project/Area Number |
19K16356
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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Research Institution | Tohoku Medical and Pharmaceutical University |
Principal Investigator |
Kanoh Hirotaka 東北医科薬科大学, 薬学部, 助教 (40774279)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | ganglioside / TLR4 / inflammation |
Outline of Final Research Achievements |
The onset and the progression of metabolic syndromes are caused by chronic inflammation mediated by innate immune receptors such as Toll-like receptors. This research project elucidated the molecular mechanisms regarding 1) ganglioside GM3, a glycosphingolipid expressed in serum and adipose tissue, acts as an endogenous TLR4 ligands/modulators, 2) GM3 could induce chronic inflammation in metabolic syndromes, and 3) the biological activity is regulated by its acyl-chain structures.
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Free Research Field |
免疫学、糖鎖生物学、脂質生物学
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Academic Significance and Societal Importance of the Research Achievements |
慢性炎症は、メタボリックシンドロームに加え、がんや自己免疫疾患、神経炎症性疾患など、現代医療の重要な課題としてあげられる疾患において、普遍的な発症・増悪因子として働く。本来は生体を病原体から防御するための免疫機構がどのようにして慢性炎症を生じるに至るのか、そのメカニズムを明らかにする上で、本研究で得られた成果は重要な発見の一つになる可能性が考えられる。
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