2020 Fiscal Year Final Research Report
Discovery of novel siderophores from microbe in acidic mossy forest and basic lake and investigation of their biosynthesis
| Project/Area Number |
19K16392
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | University of Toyama |
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Principal Investigator |
WONG CHINPIOW 富山大学, 学術研究部薬学・和漢系, 助教 (10816226)
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | 生物活性化合物 |
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| Outline of Final Research Achievements |
Total of 57 actinomycetes and acidophilic Gram-negative bacilli were isolated from soils collected at the acidic mossy forest in Brinchang and the Keracut Beach lake in Penang, Malaysia. Among them, three were identified as actinomycetes, Streptomyces koyangensis，S. lavendulae，S. atratu, and S. miharaensi and the other was identified as a Proteobacteria, Burkholderia rinojensis. Further investigation of bioactive compounds in a methanol extract from S. miharaensi led to the isolation of echinomycin and FD-991, which have be reported to be strong cytotoxic natural compounds.
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| Free Research Field |
天然物化学
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| Academic Significance and Societal Importance of the Research Achievements |
科学技術が格段に進歩した今日にあっても，医薬品の60％は未だ天然物の化学構造由来である。多剤耐性株に有効な抗生物質の早期開発等が求められる現代にあって，未知の天然生物活性物質を見い出して創薬へと展開していくことは，医薬品開発を進めるうえで極めて重要な位置を占める。今回我々は，マレーシアの土壌由来微生物が生産する化合物を調査することで，マレーシア産微生物の中には，強力な細胞毒性を示すエキノマイシンとFD-991を生産するものがいることを明らかにした。さらなる調査により，これまでに例のない新たな創薬シードが得られることが期待される。
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