2022 Fiscal Year Final Research Report
Molecular mechanisms of biological defense in macrophages: Membrane transport control mechanisms dependent on foreign particles
| Project/Area Number |
19K16519
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 48040:Medical biochemistry-related
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | メンブレントラフィック / SNAREタンパク / ファゴサイトーシス / ファゴソーム / リン酸化 / 受容体 |
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| Outline of Final Research Achievements |
Foreign particles that invade the body are processed by phagocytic cells such as macrophages. This reaction is called phagocytosis. This process is carried out by repeated membrane fusion by SNARE proteins.
SNAP23, a SNARE protein, is known to function in phagocytosis. Foreign particles that enter the body are recognized by foreign-specific receptors expressed on the surface of phagocytes, however, the relationship between the receptors and SNAP23 is not known. In this study, we found that the phosphorylation of SNAP23 Ser95 exhibits different functions (promotion or inhibition) depending on various foreign particles.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本成果は、ファゴサイトーシスにおける異物処理の優位性に関する新たな膜融合経路を示唆するものである。ファゴサイトーシスの異常は感染症や自己免疫疾患につながることから治療薬開発の標的として注目されているにもかかわらず、その分子機構はよくわかっていない。本研究はファゴサイトーシス機能を制御する分子標的薬開発のための新たなアプローチを提示する。
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