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2020 Fiscal Year Final Research Report

• Project/Area Number: 19K16553
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Niigata University
• Principal Investigator: Tani Yusuke 新潟大学, 医歯学系, 助教 (50835684)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 潰瘍性大腸炎 / 大腸癌 / DNA2重鎖切断 / DNA損傷応答

Outline of Final Research Achievements

We investigated whether DNA double strand break (DSB) and DNA damage response (DDR) can be biomarkers predicting the risk of cancer or not. We revealed (1) In cancer-bearing cases, the frequency of DSB is higher than non-cancer-bearing cases, (2) In mucosa of ulcerative colitis, the activity of DDR is lower than that of other inflammatory bowel disease, (3) DDR correlates with disease duration of ulcerative colitis, (4) The activity of DDR have small variation rerated with location in rectum, then we considered that DDR have reproducibility as the biomarker predicting the risk of cancer. We are going to examine DSB and DDR with rectal biopsy specimen.

Free Research Field

人体病理学

Academic Significance and Societal Importance of the Research Achievements

本研究では、潰瘍性大腸炎における炎症性発癌と、DNA二重鎖切断 (DSB)やDNA損傷応答 (DDR)の関連について調査した。DSBやDDRが発癌リスクを予測するバイオマーカーとして有用であるかについては、さらなる検討が必要であるが、有用であれば、学術的には炎症性発癌の分子メカニズムの解明に向けての基礎データとなり、社会的には潰瘍性大腸炎患者に行われるサーベイランスの効率化、患者の肉体的負担や、医療経済的負担の軽減に寄与する可能性がある。