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2020 Fiscal Year Research-status Report

分子異常をエビデンスとした高リスク乳頭がんの形態学的形質分析

Research Project

Project/Area Number 19K16587
Research InstitutionNagasaki University

Principal Investigator

ムサジャノワ ジャンナ  長崎大学, 原爆後障害医療研究所, 助教 (30770432)

Project Period (FY) 2019-04-01 – 2022-03-31
KeywordsPapillary carcinoma / TERT mutation / BRAF mutation
Outline of Annual Research Achievements

The 400 surgically-resected, formalin-fixed, paraffin-embedded (FFPE) thyroid FTs including 100 Japanese from one single hospital of Japan and 300 Kazakh cases from two hospital of Kazakhstan, were collected in this time. All Japanese cases and Kazakh cases were preliminary evaluated for BRAF, TERT and Ki-67. The coexistence of the two mutations was more strongly associated with high Ki-67 labeling index (>5 and >10%). Age of this patients range from 45 to 84 y.o. (mean age 68.52). In the 2017 new WHO classification was introduced and this classification brought significant changes in TNM grade and staging system of thyroid tumors. Thus, we performing re-classification of all available for our research cases.

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

We need perform re-classification of all cases by new WHO (2017) classification. For that we need review all HE staining of cases. Thus, we delay with study results.

Strategy for Future Research Activity

We request HE staining from Hospitals and reviewing them. Only 1/3 of cases are finished with re-classification.

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Published: 2021-12-27  

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