Establishment of mucosal healing of ulcerative colitis by ultra-magnified endoscopy and establishment of related cancer diagnostic methods

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K16592
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Keio University
• Principal Investigator: TAKABAYASHI Kaoru 慶應義塾大学, 医学部(信濃町), 講師 (60573342)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 潰瘍性大腸炎関連腫瘍 / 潰瘍性大腸炎 / 拡大内視鏡

Outline of Final Research Achievements

The diagnosis of ulcerative colitis associated neoplasia (UCAN) has been considered difficult because of its various forms. In the present study, we sought to clarify the endoscopic characteristics of flat-type UCAN, which is particularly difficult to diagnose.
Among patients diagnosed with UCAN, we extracted the characteristics of endoscopic findings in patients with flat-type UCAN who underwent magnified endoscopic observation, and from FY 2019, we performed further detailed magnified endoscopic observation of mucosal surfaces with these characteristics. In addition, histopathological comparison of biopsy, endoscopically treated specimens, and surgical specimens was also performed, and finally, endoscopic morphological characteristics of flat-type UCAN by magnifying endoscopy were clarified.

Free Research Field

消化器内視鏡学

Academic Significance and Societal Importance of the Research Achievements

潰瘍性大腸炎関連腫瘍は病勢の予後を左右する非常に重要な偶発症であり、その発症のriskは30年で6-8％と報告されており、潰瘍性大腸炎の罹病期間にそって増加することが報告されている。このため、その早期診断および早期治療は非常に重要であるが、潰瘍性大腸炎関連腫瘍は様々な形態を呈するため、これまではその内視鏡診断は困難とされていた。今回、このうち特に診断が困難とされる平坦型潰瘍性大腸炎関連腫瘍の内視鏡的特徴を拡大内視鏡を用いることで明らかにした。今回の成果により潰瘍性大腸炎の拾い上げが容易になることが予想され、それにより潰瘍性大腸炎患者全体の生命予後改善につながることが期待される。