2021 Fiscal Year Final Research Report
Elucidation of the mechanisms of epidermal aging
| Project/Area Number |
19K16607
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 49030:Experimental pathology-related
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| Research Institution | The University of Tokyo (2021)
Tokyo Medical and Dental University (2019-2020) |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 皮膚 / 幹細胞 / 老化 |
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| Outline of Final Research Achievements |
In order to understand the physiological aging mechanism of the epidermis, we analyzed changes in skin function and stem cell behavior during aging using the mouse epidermis as a model.
Environmental factors that cause DNA damage, such as radiation and UVB, lead to functional decline similar to that of aged skin.Fate analysis revealed that DNA damage of epidermal stem cell leads to differentiated and then withdraw from the basal layer of the epidermis during homeostasis in young mice.Similar results were demonstrated in three-dimensional culture using human epidermal cells.
These results indicating that tissue regeneration by withdrawal of DNA damaged stem cells from the basal layer is a conserved maintenance mechanism of epidermal stem cell pool throughout the species.
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| Free Research Field |
幹細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、加齢性の皮膚機能低下において表皮幹細胞の加齢変化、すなわち幹細胞老化が組織における老化形質出現の中心的な役割を果たすこと、また、幹細胞においてDNA障害を引き起こす種々の環境因子が組織老化促進因子としての重大なリスクファクターとなりうることを示した。本成果に基づく幹細胞老化の抑制を作用点とした、超高齢化社会における抗老化技術の開発へと繋がるものと期待できる。
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