2021 Fiscal Year Final Research Report
Elucidation of the function of DNA damage tolerance in UV-induced skin cancer development
| Project/Area Number |
19K16616
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 49030:Experimental pathology-related
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | REV7 / DNA損傷トレランス / 紫外線 / 発癌 / 損傷乗り越えDNA合成 / 突然変異 / DNAポリメラーゼ |
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| Outline of Final Research Achievements |
To elucidate the involvement of REV7 in ultraviolet (UV)-induced skin cancer development, analyses using culture cells and genetically modified mouse conducted. Using culture cells, we revealed that REV7 contributed significantly to cell survival after UV irradiation and was also involved in the introduction of mutations. On the other hand, no difference in the timing or number of UV-induced tumors was observed between Polh-deficient mice and Polh-deficient / Rev7-heterodeficient mice, suggesting that loss of REV7 function may not be sufficient in Rev7 heterodeficient mice.
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| Free Research Field |
分子生物学、実験病理学
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| Academic Significance and Societal Importance of the Research Achievements |
REV7は紫外線（UV）に対する細胞生存に大きく寄与しており、皮膚の恒常性の維持に関与している可能性がある。また、REV7はUVによる突然変異の導入にも関与しているため、皮膚癌の発症に関与している可能性が十分考えられる。本研究を継続することにより、UVによる皮膚癌の発生におけるREV7の役割が明らかとなり、皮膚癌の予防や治療に繋がると期待される。
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