2021 Fiscal Year Final Research Report
Elucidate the immune modulation mechanism of muscle and bone.
| Project/Area Number |
19K16688
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 49070:Immunology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 運動 / 免疫 / 免疫細胞療法 |
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| Outline of Final Research Achievements |
It has been suggested that exercise may change the immune cell dynamics in an individual's body, and it is thought that by studying the relationship between exercise and immunity, new immunotherapeutic targets can be explored. In this study, we investigated the regulatory mechanism of cell dynamics by analyzing the effect of combined exercise on the effect of immuno-cell therapy in a cancer-bearing mouse model.
We succeeded in constructing an experimental system in which tumor growth is suppressed by exercise, and it was suggested that it is more effective to exercise for a short period of time multiple times with an interval than for long-term continuous exercise. Furthermore, it was confirmed that the tumor suppressive effect can be observed depending on the tumor position even by electrical stimulation of the muscle.
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| Free Research Field |
免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果は、養子免疫療法において、運動等の外的刺激により、治療効果を改善する事が可能である事を意味しており、今後の免疫療法における新しい介入手段となる事が期待出来る。薬剤ではない、新しい手法であるため、既存の治療法との併用が容易である。
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