2021 Fiscal Year Annual Research Report
The role of LILRB4 on MDSC-mediated immunosuppression in tumor environment
| Project/Area Number |
19K16705
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| Research Institution | Tohoku University |
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Principal Investigator |
蘇 美慈 東北大学, 加齢医学研究所, 助教 (00812116)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | LILRB4 / gp49B / MDSC / Immunosuppression / tumor metastasis / miRNA |
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| Outline of Annual Research Achievements |
In this study, we report that the leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4, murine ortholog gp49B) orchestrates the polarization of MDSCs to exhibit pro-tumor phenotypes. Our results reveal that LILRB4/gp49B promotes MDSC-mediated tumor metastasis by regulating the M2-polarization of MDSCs and suppressing the secretion of miR-1 family miRNAs, which facilitate tumor migration and invasion. We have published our results on the Oncolmmunology (DOI: 10.1080/2162402X.2022.2060907).
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