A study on the mechanism regulating cell motility upon metabolic alterations by PFK1 inhibition

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K16728
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Tokyo University of Pharmacy and Life Science (2020); Institute of Physical and Chemical Research (2019)
• Principal Investigator: Kobayashi Hiroki 東京薬科大学, 生命科学部, 助教 (30528683)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: がん代謝 / 解糖系 / 細胞遊走 / PFK1

Outline of Final Research Achievements

Understanding of cancer metabolism can lead to the development of new anti-cancer therapies. We have found that the alteration of energy metabolism by PFK1 inhibition in cancer cells enhances cell motility, which is involved in cancer metastasis. In this study, we tried to elucidate mechanisms underlying this phenomenon. We performed metabolic analyses, gene expression analyses, and phonotypic analyses using pharmacological and genetic approaches. Consequently, we succeeded in identifying the responsible gene that enhances the motility of cancer cells upon alteration of energy metabolism.

Free Research Field

がん、代謝、ケミカルバイオロジー

Academic Significance and Societal Importance of the Research Achievements

エネルギー代謝ががん細胞の悪性化にどのように関わるか、その一端を解明することができた。この成果はがんの治療戦略構築の一助となり、将来的に人類の健康に貢献しうる。