Development of the innovative new treatments targeting cancer metabolism utilizing large GI cancer cohorts

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K16750
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Kumamoto University
• Principal Investigator: KOSUMI Keisuke 熊本大学, 病院, 非常勤診療医師 (50594884)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 消化器癌 / 腫瘍微小環境 / がん代謝 / 腫瘍免疫 / マイクロバイオーム / バイオマーカー

Outline of Final Research Achievements

The aim of the current study is to contribute to the development of the innovative new treatments targeting cancer metabolism utilizing large GI cancer cohorts. We found that the amount of intratumoral Fusobacterium nucleatum DNA is associated with a diminished peritumoral lymphocytic reaction and peripheral lymphocyte. We also found the significant association between Fusobacterium nucleatum and LSD1 expression. Our findings support the possible influence of intratumoral Fusobacterium nucleatum on anti-tumor immunity and cancer metabolism.

Free Research Field

外科腫瘍学

Academic Significance and Societal Importance of the Research Achievements

本研究では、腫瘍微小環境においてがん代謝・腫瘍免疫・微生物がどのように関連し癌進展に寄与するかを明らかにすべく、グローバルかつ膨大な消化器癌データベースを用い検討を行った。腫瘍内Fusobacterium nucleatumが腫瘍免疫及びがん代謝に関連する可能性が示唆され、今後の発癌予防および免疫を介したがん治療に寄与できる可能性が示唆された。