Characteristics of pancreatic cancer's stroma based on clock genes and its applications to image diagnosis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K16763
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Hirosaki University
• Principal Investigator: Goto Shintaro 弘前大学, 医学研究科, 助教 (00826901)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 膵癌 / 癌微小環境 / 癌関連線維芽細胞 / 時計遺伝子 / 放射線画像診断

Outline of Final Research Achievements

This study demonstrated that time density curve (TDC) which represents the time-dependent change of tumor's contrast effect correlate with the densities of cancer cells and fibroblasts in pancreatic cancer. In addition, this study demonstrated that the patterns of TDC changed before and after neoadjuvant chemotherapy (NAC). In conclusion, this study revealed it is possible to predict histological therapeutic effect by NAC with the TDC before and after NAC.

Free Research Field

病理学

Academic Significance and Societal Importance of the Research Achievements

膵癌の術前化学療法の効果判定は病理学的に大きな課題となっており，画像診断と組み合わせることで，旧来の効果判定法にはない臨床所見に則した評価が可能となった。また，診療上，化学療法が腫瘍に確実に効果を与えているかを画像診断で適切に評価することが可能となり，適切な手術時期の決定に寄与すると考えられる。