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2019 Fiscal Year Research-status Report

SynNotch EV cells-flexible ”CAR T”-cells

Research Project

Project/Area Number 19K16849
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

NORDIN JOEL  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 客員研究員 (70836064)

Project Period (FY) 2019-04-01 – 2021-03-31
KeywordsImmunology / Muscle / CART / Gene therapy
Outline of Annual Research Achievements

The aim of this project is to utilise Syn-Notch EV cells to deliver macromolecular to cells. EVs have been shown to be able to transfer macromolecules to cells. Syn-Notch EV cells would deliver engineered EVs to specific cells after activation of the Syn-Notch receptor by a user defined antigen.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

I am proceeding study according to plan.

Strategy for Future Research Activity

I am planning to test whether the Syn-Notch EV cells could deliver engineered EVs to specific cells after activation of the Syn-Notch receptor by a user defined antigen.

  • Research Products

    (2 results)

All 2019

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results)

  • [Journal Article] Autoimmune response and its long‐term consequences after exon‐skipping therapy in a Duchenne muscular dystrophy mouse model2019

    • Author(s)
      Nordin Joel Z、Aoki Yoshitsugu
    • Journal Title

      The Journal of Pathology

      Volume: 249 Pages: 271~273

    • DOI

      10.1002/path.5327

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles2019

    • Author(s)
      Kuhn Jasmin、Klein Philipp M.、Al Danaf Nader、Nordin Joel Z.、Reinhard S?ren、Loy Dominik M.、H?hn Miriam、El Andaloussi Samir、Lamb Don C.、Wagner Ernst、Aoki Yoshitsugu、Lehto Taavi、L?chelt Ulrich
    • Journal Title

      Advanced Functional Materials

      Volume: 29 Pages: 1906432~1906432

    • DOI

      10.1002/adfm.201906432

    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2021-01-27  

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