2019 Fiscal Year Research-status Report
Role of sleep in creativity and problem solving
| Project/Area Number |
19K16892
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
アブドゥ カリーム 富山大学, 学術研究部医学系, 助教 (00833609)
|
|---|
| Project Period (FY) |
2019-04-01 – 2021-03-31
|
| Keywords | Inference |
|---|
| Outline of Annual Research Achievements |
In order to unveil how our brain uses the existing knowledge during sleep to generate new information and hence understand the mechanism of creativity, I successfully established the sleep-dependent transitive inference behavior paradigm as a model for creative problem solving in which mice can infer correctly based on their previous experiences. Moreover, I identified the brain region (Anterior cingulate cortex, ACC) which is necessary for the emergence of the correct inference. Currently, I have got an interesting promising result in defining the brain circuit that is sufficient for the induction of artificial inference during sleep. In the near future, I will start investigating the neuronal dynamic mechanism of the emergence of inference during sleep by Ca2+ imaging technique.
|
| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
My progress is going well according to my plan. Establishing the behavior paradigm was the longest step because it needs trouble shooting and repeating the training for mice. The subsequent experiments were running well because I am working with my full power and capabilities.
|
| Strategy for Future Research Activity |
My future plan is to investigate the neuronal dynamic mechanism of the emergence of inference during sleep by Ca2+ imaging technique. I will extract the ensembles (activity patterns) corresponding to the inference and their temporal dynamics to dissect the mechanism by which the inference information is emerged. Then, I will establish the causal link between the emerged ensembles during sleep and the inference performance by combining ultra-thin Fluorescence Endoscope Imaging System (U-FEIS) with multi-independent light stimulation system (MILSS).
|
| Causes of Carryover |
In the first year, I purchased the majority of items that I need in my research study by the grant money. However, to make the maximum benefit from the items purchased, I sometimes use common materials in our lab purchased by my professor grant instead of buying them again, that’s the reason why there is remaining money from first year. I would like to use the remaining money in the second year because I need to buy more antibodies and cannulas for surgery in mice brain. Also, I need to order analysis software programs to accelerate my data analysis
|
