Validation of a neuroinflammation-induced schizophrenia model in primates and establishment of Neuroimaging biomarkers

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K16896
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 51020:Cognitive and brain science-related
• Research Institution: Kyoto University
• Principal Investigator: Konoike Naho 京都大学, ヒト行動進化研究センター, 特定助教 (80645169)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 霊長類 / 脳波 / 聴性定常反応 / 統合失調症 / 動物モデル

Outline of Final Research Achievements

Neuroinflammation during the embryonic period and early postnatal period has recently been postulated to be a factor in neuropsychiatric disorders such as developmental disorders and schizophrenia. In our laboratory, we have developed a disease model based on the neuroinflammation hypothesis in non-human primates.In this study, we have continued behavioral assessment and noninvasive EEG measurements in these models, rhesus macaques and common marmosets. We found that the disease models exhibit EEG abnormalities similar to those of schizophrenia patients. In the final year of the project, noninvasively recorded EEG data from humans, macaque monkeys, and marmosets were used to evaluate the bio-markers of schizophrenia, namely auditory steady-state responses.

Free Research Field

認知神経科学

Academic Significance and Societal Importance of the Research Achievements

精神疾患、とくに統合失調症や発達障害の霊長類モデルは開発途上にある。現在、作出している霊長類モデルの妥当性および有用性が確認されれば、統合失調症や発達障害の病態解明や新しい治療法の開発につながる可能性がある。