2022 Fiscal Year Final Research Report
Investigation of brain regions regulating pair bond in primates: analysis by electrical stimulation and pharmacogenetic techniques
| Project/Area Number |
19K16901
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 51020:Cognitive and brain science-related
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| Research Institution | Hokkaido University (2020-2022)
Institute of Physical and Chemical Research (2019) |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 家族の絆 / 霊長類 / マーモセット / 愛着行動 / 養育行動 / 親子関係 |
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| Outline of Final Research Achievements |
The ultimate goal of this research is to elucidate the brain mechanisms of family bond. Although our initial target was pair bond, we decided to focus on infant attachment because we occasionally found some marmosets show atypical behavior similar to human attachment disorder.
We revealed that infant marmoset modified their attachment behavior according to the parenting style of each caregiver. On the other hand, artificially reared infants could not develop the adaptive use of attachment behaviors or age-appropriate autonomy. In addition, the received care in childhood affected later sociality and caused paradoxical negative responses towards social and non-social rewards. These characteristics were similar to those in human, indicating that a marmoset is a useful animal model for attachment research.
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| Free Research Field |
親和性社会行動
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| Academic Significance and Societal Importance of the Research Achievements |
幼少期の愛着形成は、情緒や社会性の発達の基盤となり、成長後の心の健康や対人関係にも重要な役割を果たす。幼少期に十分な愛着形成が出来ず、周囲の人々との人間関係に困難を生じている状態を「愛着障害」と呼び、近年問題視されている。しかし、愛着形成や愛着障害の脳内機構は未だ明らかにされていない。
本研究により、マーモセットの親子関係・愛着行動にヒトと類似した多くの特徴が見出された。今後、マーモセットをモデル動物として愛着形成の脳内機構を研究することで、ヒトの愛着形成の機序解明や、愛着障害の理解や対策につなげられると期待される。
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