2021 Fiscal Year Final Research Report
Elucidation of the mechanism of dopaminergic cell death based on the analysis of a novel mouse model of Parkinson's disease.
Project/Area Number |
19K16914
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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Research Institution | Kyoto University |
Principal Investigator |
Ikuno Masashi 京都大学, 医学研究科, 特定助教 (30808960)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | パーキンソン病 / アルファシヌクレイン / 神経細胞死 / モデルマウス / 前駆病態 |
Outline of Final Research Achievements |
In order to prevent the onset or progression of Parkinson's disease, it is important to understand the pathogenesis of the disease in the prodromal phase, before the dopamine nerves are reduced in large amounts. It is known that Parkinson's disease manifests various abnormalities in areas other than the brain from the prodromal stage. In this study, I used a mouse model of Parkinson's disease in the prodromal stage and analyzed its blood metabolites. The results showed an increase in isobutyricarnitine and pyrimidine nucleosides, which are thought to be associated with mitochondrial abnormalities. These results suggest that systemic mitochondrial dysfunction already exists in Parkinson's disease, even in its prodromal stage.
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Free Research Field |
臨床神経学
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Academic Significance and Societal Importance of the Research Achievements |
近年、パーキンソン病を始めとした中枢神経疾患における中枢神経以外の臓器との関連が注目されています。特にパーキンソン病では腸脳連関と言って脳の病態と腸管の状況が関連していることが知られています。本研究はパーキンソン病モデルマウスでも脳以外の異常が存在することを示すとともに、パーキンソン病の予防のための前駆期・全身病態の重要性を示唆する成果であると言えます。
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