An exploratory investigation of factors influencing effect of exercise on frailty in older patients with heart failure

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K16986
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Yokohama City University
• Principal Investigator: KONISHI Masaaki 横浜市立大学, 附属病院, 講師 (60530152)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: フレイル / 心不全

Outline of Final Research Achievements

A total of 34 cases were enrolled at Yokohama City University Hospital and 110 cases at Yokohama City University Medical Center, the facilities for this study. Data from these cases were integrated to identify factors affecting the effect of exercise therapy on frailty in elderly heart failure patients. Ferritin, serum iron, total iron binding capacity, carnitine fraction (total carnitine, free carnitine, acylcarnitine), TNF-α (high sensitivity), and interleukin-6 (IL-6) were measured in the Yokohama City University Hospital cases, and factors affecting the effect of exercise therapy were identified as subanalysis. These results will be submitted to an English-language medical journal.

Free Research Field

循環器内科

Academic Significance and Societal Importance of the Research Achievements

本研究の結果は、過去の研究では明らかになっていなかった、高齢心不全患者のフレイルに対する運動療法の効果に影響する因子を明らかにすることができた。この結果をもとに、フレイルを合併した高齢心不全患者に運動療法を行う上での注意点を認識することができた。またこれらの指標は、高齢心不全患者のフレイルを改善するために介入すべき項目の一部となる可能性が示唆される。これらの項目に対する介入研究をデザインする根拠となるため、今後の研究のために重要な基礎的結果となった。