A multifaceted study on heterogeneity in attention-deficit/hyperactivity disorder

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K17068
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Nara Medical University
• Principal Investigator: Nakanishi Yoko 奈良県立医科大学, 医学部, 研究員 (80458025)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 近赤外線スペクトロスコピー / 注意欠如多動症 / 虐待

Outline of Final Research Achievements

he presence or absence of exposure to adversarial childhood experiences in ADHD was investigated; an ACE score of 0 was considered an ACE exposure - group, and an ACE score of 1 or greater was considered an ACE exposure + group. Background information, social functioning (LSAMI), ADHD symptom severity (CAARS), cognitive function (WISC-III, CAT), brain imaging (MRI), and neurophysiological testing (ERP, NIRS) were performed on all subjects.ASD with ADHD group 31 subjects, ASD without ADHD 43 and 41 Control subjects were recruited and analyzed. No significant differences were found in the analysis of neurophysiological tests among the three groups. No relationship between NIRS values and CATS or ACE, which are indicators of abuse, was also found.

Free Research Field

神経生理学

Academic Significance and Societal Importance of the Research Achievements

ADHDを虐待の有無によって細分化を試みたが明らかな結果を得ることができなかった。さまざまな精神疾患では虐待の有無によってその臨床症状や生物学的指標が異なることが報告されているが、ADHDではそのような結果にはならなかった。今後はさらに症例数を増やすこと、ASDを背景としてもっている患者を対象としていたので純粋なADHD患者を対象にする必要がある。少なくとも虐待は多くの精神疾患に影響を与えうるものであり、引き続き研究を継続する必要がある。