Circadian rhythm sleep-wake disorder in outpatients with schizophrenia and its association with psychosocial functioning

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17098
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Matsui Kentaro 国立研究開発法人国立精神・神経医療研究センター, 病院 臨床検査部, 医長 (30647152)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 統合失調症 / 概日リズム睡眠・覚醒障害 / 有病率 / 精神病症状 / 社会機能障害

Outline of Final Research Achievements

The prevalence of circadian rhythm sleep-wake disorder (CRSWD) among patients with schizophrenia was not clear. The effect of comorbid CRSWD on such patients has also not been fully evaluated yet. Of the 105 patients with schizophrenia, 19 (18.1%) had CRSWD. There were trends toward higher Brief Psychiatric Rating Scale (BPRS) and lower Global Assessment of Functioning (GAF) scores in the CRSWD group than in the non-CRSWD group, although these did not reach statistical significance following a false discovery rate correction. Among the BPRS subitems, the anxiety scores were significantly higher in the CRSWD group than in the non-CRSWD group (p < 0.01). Comorbidities of CRSWD may affect psychopathological characteristics and psychosocial functioning.

Free Research Field

精神医学

Academic Significance and Societal Importance of the Research Achievements

本研究は維持期の統合失調症患者における概日リズム睡眠・覚醒障害（CRSWD）の有病率や、精神病症状・社会機能との関係について調べた初めての研究であり、実臨床において極めて重要な情報を提供することができたと考えている。統合失調症に併存するCRSWDにより二次的に生じた不眠症状はしばしば見過ごされている可能性があり、適切な診断および介入が、患者の社会機能の向上に寄与する可能性がある。今後の研究でCRSWDの併存が統合失調症患者の長期予後に及ぼす影響について検証されることが望ましい。