2021 Fiscal Year Final Research Report
Investigation about the effect of amyroid deposition on sequelae and brain atrophy after brain injury
Project/Area Number |
19K17110
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 52030:Psychiatry-related
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Research Institution | Kyoto University |
Principal Investigator |
Ubukata Shiho 京都大学, 医学研究科, 特定助教 (40738960)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 外傷性脳損傷 / アミロイド / 神経心理学 / 脳萎縮 |
Outline of Final Research Achievements |
Amyroid PET image was conducted with the participants with 12 patients with focal brain injury and 8 with diffuse axonal injury. Newly developed 18F-FPYBF-2 was utilized as amyroid tracer. As SUVR, the ratio to the score of cerebellum was calucurated and used as the index of accumulation onto the grey matter. Grey matter was divided into 90 region of interest by the Automated Anatomical Labelling (AAL) atlas. As a result, significantly higher accumulation was detected in temporal and occipital lobe only with the diffuse axonal injury group compared to the healthy group. As a longitudinal survey, MRI image was obtained twice with 17 patients, and PET imging was obtained twice with 6 patients. In the future, we plan to investigate the corelation between the change of amyroid accumulation with the brain volume atrophy shown in MRI image. In addition, amyroid deposition was observed onto white matter and brain stem, we plan to analyze the data about these regions in future.
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Free Research Field |
脳科学
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Academic Significance and Societal Importance of the Research Achievements |
脳外傷は将来的な認知症の危険因子とされてきたが、それを実証した研究は無いに等しい。本研究の結果、慢性期の外傷性脳損傷例におけるアミロイドの沈着パターンが変性疾患とは異なることが分かった。このことは、脳外傷が必ずしも将来的な認知症の危険因子ではない、あるいは将来的な認知症が従来知られている脳萎縮とは異なる機序で生じることを示唆している。本邦の外傷性脳損傷患者の多くは交通外傷の被害者で、本人・家族ともに予後について不安を強く抱えている。今後、経時的変化を検討し、脳外傷と将来的な認知症の関係について従来より正確な情報を提供できるようにすることは、社会的に大きな意義があると考えられる。
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