Prediction of the radiosensitivity against cancer based on the redox balance of serum albumin

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17137
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyoto University
• Principal Investigator: Inoue Minoru 京都大学, 医学研究科, 助教 (20826010)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: がん / 放射線治療 / 血清アルブミン / 好中球細胞外トラップ / ナトリウム・カルシウム交換体

Outline of Final Research Achievements

We demonstrated that oxidation of serum albumin is not associated with the efficacy of radiotherapy for the patients with pancreatic cancer. However, albumin oxidation is associated with the higher plasma NETs level, higher proportion of distant metastasis, and lower overall survival. We will report the result as a research article after all of the samples are examined. We also investigated potent triggers of NETs in pancreatic cancer. An amiloride analog 5-(N-ethyl-N-isopropyl)-Amiloride（EIPA) is known to inhibit the growth of pancreatic cancer cells and thus is considered to be a promising drug for pancreatic cancer. However, we demonstrated that EIPA trigger NETs release via inhibition of sodium-calcium exchange. The research article was accepted by Redox Biology.

Free Research Field

放射線治療

Academic Significance and Societal Importance of the Research Achievements

本研究成果の社会的意義として、血清アルブミンの酸化度を治療前に測定する事で、膵がん患者の予後を予測し得ることが挙げられる。今後、同予測に応じた治療内容の選択が可能となるかもしれない。本研究成果の学術的意義として、膵がんの転移におけるNETsの重要性が示唆された事から、NETsの生成機構の解明に関する基礎研究の促進につながる事が挙げられる。これにより、NETs阻害剤を用いた転移抑制戦略への展開が期待される。