Development and clinical application of multi-pool analysis using high-resolution 3D CEST imaging

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K17145
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyushu University
• Principal Investigator: Wada Tatsuhiro 九州大学, 大学病院, 診療放射線技師 (60444832)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 磁気共鳴医学

Outline of Final Research Achievements

The purpose of this study was to establish an accelerated 3D CEST imaging method combined with compressed sensing and sensitivity encoding (CS-SENSE), and to apply it clinically to patients with brain tumors.
The 3D CEST imaging combined with CS-SENSE was able to obtain image quality comparable to that of conventional 2D CEST imaging in a self-made phantom and in patients with brain tumors. It also proved to be equivalent to conventional 2D CEST imaging in the grading of glioma malignancy. Furthermore, by applying multi-pool analysis, 3D APT imaging, NOE imaging, and MTR imaging could be obtained.

Free Research Field

放射線技術学

Academic Significance and Societal Importance of the Research Achievements

神経膠腫において最も悪性の膠芽腫は全般的に不良である。その原因として、悪性度の高い部分を取り残してしまうことがあげられる。従来の2D CESTイメージングは１断面のみの画像取得という問題があった．
本研究で開発した3D CESTイメージングは，腫瘍全体を含めることが可能である．また，神経膠腫のCESTイメージングの信号強度は，撮像断面により変化することが本研究にて明らかになった．3D CESTイメージングを用いることで，神経膠腫の悪性度診断の精度向上が期待される．