2020 Fiscal Year Final Research Report
Comprehensive 4D Flow MRI assessment for hypertrophic obstructive cardiomyopathy
| Project/Area Number |
19K17151
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | 4D Flow MRI / CFD / energy loss / turbulent kinetic energy / HCM / aortic stenosis / pressure loss / MRI |
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| Outline of Final Research Achievements |
We developed the robust framework to estimate pressure loss in hypertrophic cardiomyopathy by using 4D Flow MRI. The framework have revealed that pressure loss correlates well to left ventricular mass in asymptomatic patients with hypertrophic cardiomyopathy, which indicates this method is able to discriminate the patients corresponding to each pathophysiology. Furthermore, we developed this method and showed that it can be applied to postoperative cases of aortic dissection.
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| Free Research Field |
放射線医学
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| Academic Significance and Societal Importance of the Research Achievements |
4D Flow MRIを用いた圧較差推定(エネルギー損失推定)の有用性は期待されたる所だが、実際の臨床的なインパクトに繋がる報告は数少ない。我々の研究成果がその端緒となり、更なる研究発展に繋がる事が期待出来る。
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