2021 Fiscal Year Final Research Report
Chemoselective methionine 18F-fluorination on unprotected peptides for positron-emission tomography imaging
| Project/Area Number |
19K17156
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | National Institutes for Quantum Science and Technology |
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Principal Investigator |
Hu Kuan 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 先進核医学基盤研究部, 研究員 (00827678)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | peptide / fluorine 18 / radiolabeling / PET / cancer / diagnosis |
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| Outline of Final Research Achievements |
PET imaging is a highly clinically relevant technique for disease diagnosis. A series of PET radiotracers have been approved for clinical use. As one class of PET tracers, peptide-based radiotracers have many advantages due to their favorable pharmacokinetics and biodistribution profiles. The development of peptide-based PET tracers is emerging as one of the most vital task for nuclear medicine, while the direct labeling of unprotected peptides without prothestic group remains a challenge. 18F is an positron emission radionuclide with a decay hald-life of 109.8 min, showing a good matchness with the biological half-life of peptides. In this context, the radiolabeling of peptide with 18F is attracting more and more attention from both industry and acedamia. In this project, we developed a non-prothestic, bioconjugated method for direct 18F labeling of unprotected peptides with methionine residues.The method is generally applicable for radiolabeling any Met-containing peptides.
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| Free Research Field |
放射線科学関連
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| Academic Significance and Societal Importance of the Research Achievements |
This resarch results may help develop imaging agents that can be used for disease diagnosis in hospticals. Our research provide a feasible method to synthesize imaging agents via an more financially econimic way, thus save cost for patients.Moreover, it can reduce radiation to the human body.
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