Evaluation and establishment of criteria for deformable image registration uncertainty on 4D dose accumulation

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17167
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyoto University
• Principal Investigator: Miyabe Yuki 京都大学, 医学研究科, 客員研究員 (60522505)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 放射線治療 / 4次元治療計画 / 非剛体レジストレーション

Outline of Final Research Achievements

In order to promote the clinical application of deformable image registration(DIR) in 4D radiotherapy treatment planning, patient specific quality assurance(QA) methods and analysis program were developed for DIR accuracy evaluation. The dosimetric errors induced by DIR methods in 4D dose accumulation were evaluated in lung, liver, pancreas, head and neck, and prostate cancer cases. In addition, a software to visualize the uncertainty in the evaluation of the acculumated 4D dose distribution and dose volume histogram was developed, and it is useful to QA of DIR in clinical practice. The results of this study will facilitate clinical application for high-precision radiotherapy such as 4D radiotherapy and Adaptive radiotherapy.

Free Research Field

医学物理

Academic Significance and Societal Importance of the Research Achievements

本研究で開発した解析評価手法および積算線量分布の不確実性を可視化表示できるシステムは臨床現場において患者個別の解析評価を容易にする。データベースも構築しており、今後、症例数を追加して解析を進め各評価指標の基準値を提供することができれば、DIRの臨床応用が進み正確な積算線量評価が可能となる。その結果、4次元放射線治療やAdaptive放射線治療といった高精度放射線治療の臨床応用と適応拡大、治療成績向上につながることが期待できる。