Development of simultaneous imaging method of PET/SPECT multi-nuclide using a scintillation active collimator

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17191
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Tohoku University
• Principal Investigator: Yoshino Masao 東北大学, 金属材料研究所, 助教 (30789938)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 放射線検出器 / PET / SPECT / 多核種同時撮像

Outline of Final Research Achievements

In this study, we developed a BGO-SAC detector designed by Monte Carlo simulation using GATE and succeeded in simultaneous quantitative imaging of PET (22Na) and SPECT (57Co) nuclides. For PET nuclide (22Na), we achieved more than 10 times better performance in spatial resolution, detection efficiency, and signal-to-noise ratio compared with conventional SPECT systems that have been studied for simultaneous multi-nuclide imaging.

Free Research Field

放射線計測

Academic Significance and Societal Importance of the Research Achievements

本研究が実用化され、PET核種とSPECT核種の同時定量撮像が可能となった際には、核医学の分野において、これまで不可能であったRI内用療法の治療効果予測とその効果判定が1度の測定で可能となり、RI内用療法の安全性・安心の確保につながる。症例の一例としては、甲状腺癌、前立腺癌骨転移、神経内分泌腫瘍、褐色細胞腫、前立腺癌、乳癌における治療効果予測と効果判定に活用がすることが可能であり、国民の健康・死亡リスク低減の観点から、本研究の社会的意義は大きい。