2023 Fiscal Year Final Research Report
Elucidation of the pathophysiology of contrast-induced nephropathy through imaging assessment of renal blood flow and renal oxygen saturation, and development of transarterial therapeutic methods.
| Project/Area Number |
19K17228
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 選択的腎動脈造影 |
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| Outline of Final Research Achievements |
This study offers animal experiment insights on how contrast agent administration routes affect kidney damage risk. Intraarterial administration causes more severe kidney damage compared to intravenous routes. Hydration with saline mitigated the severity of nephropathy when administered intraarterially, improving outcomes. The findings suggest that the volume of contrast reaching the kidneys increases intratubular pressure and blood viscosity, leading to potential ischemia. Additionally, saline hydration proved more effective intraarterially, suggesting that targeted hydration strategies could enhance management of contrast media effects on kidneys, refining clinical protocols to minimize damage in contrast-enhanced diagnostic procedures.
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| Free Research Field |
造影剤腎症
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| Academic Significance and Societal Importance of the Research Achievements |
この研究は、広範囲に使用されているヨード造影剤の腎臓への影響を評価し、特に経腎動脈的な投与が腎機能に及ぼす直接的な影響を明らかにしています。高齢化社会の進展と共に腎機能障害を持つ人口が増加する中、異なる投与経路による腎障害のリスクを詳細に分析しました。この研究は、造影剤による腎障害を最小限に抑えるための臨床指針の改善に貢献し、安全で効果的な造影剤の使用法を開発することで、患者の安全を保ちながら医療の質を向上させることを目指しています。その結果、医師にとって重要な判断基準を提供し、患者の治療計画の策定を支援することが期待されています。
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