Development of Radiosensitizing Fiducial Marker by Nano Particle Delivery

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17235
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kobe University
• Principal Investigator: Wang Tianyuan 神戸大学, 医学部附属病院, 医学研究員 (90757288)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 放射線治療用マーカー / 生体吸収性材料

Outline of Final Research Achievements

This research is a novel development of an implantable therapeutic marker capable of delivering inorganic nanoparticles. The applicants developed independently using the radiosensitizing effect as a factor for radiotherapy . We found that nanoparticles of titanium oxide generate a large amount of hydroxyl radicals upon X-ray irradiation. In order to extremely improve this sensitization efficiency, we aim to develop a new therapeutic device that utilizes a visible metal marker that is implanted near the tumor, and the nanoparticles released from the marker are directly incorporated into the tumor, producing the greatest anti-tumor effect during the irradiation period.

Free Research Field

放射線腫瘍学

Academic Significance and Societal Importance of the Research Achievements

放射線治療マーカーを利用したナノ粒子デリバリーデバイスはまだ報告されず、本申請は医工連携共同研究の中から発案し、独創的な研究開発と言える。放射線治療装置・デバイスに関してはその80％以上が海外メーカー製品であり、国内独自の医療機器開発が強く期待される。本研究開発が達成できれば、放射線治療視認性マーカーが留置される患者症例に対してすべて適応になると考えられ、将来的に幅広く臨床応用することが期待される。