2020 Fiscal Year Final Research Report
Development of Radiosensitizing Fiducial Marker by Nano Particle Delivery
Project/Area Number |
19K17235
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 52040:Radiological sciences-related
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Research Institution | Kobe University |
Principal Investigator |
Wang Tianyuan 神戸大学, 医学部附属病院, 医学研究員 (90757288)
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Project Period (FY) |
2019-04-01 – 2021-03-31
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Keywords | 放射線治療用マーカー / 生体吸収性材料 |
Outline of Final Research Achievements |
This research is a novel development of an implantable therapeutic marker capable of delivering inorganic nanoparticles. The applicants developed independently using the radiosensitizing effect as a factor for radiotherapy . We found that nanoparticles of titanium oxide generate a large amount of hydroxyl radicals upon X-ray irradiation. In order to extremely improve this sensitization efficiency, we aim to develop a new therapeutic device that utilizes a visible metal marker that is implanted near the tumor, and the nanoparticles released from the marker are directly incorporated into the tumor, producing the greatest anti-tumor effect during the irradiation period.
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Free Research Field |
放射線腫瘍学
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Academic Significance and Societal Importance of the Research Achievements |
放射線治療マーカーを利用したナノ粒子デリバリーデバイスはまだ報告されず、本申請は医工連携共同研究の中から発案し、独創的な研究開発と言える。放射線治療装置・デバイスに関してはその80%以上が海外メーカー製品であり、国内独自の医療機器開発が強く期待される。本研究開発が達成できれば、放射線治療視認性マーカーが留置される患者症例に対してすべて適応になると考えられ、将来的に幅広く臨床応用することが期待される。
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