Portal vein embolization using N-butyl-2-cyanoacrylate, Lipiodol, Ethanol in swine.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K17278
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Wakayama Medical University
• Principal Investigator: Kamisako Atsufumi 和歌山県立医科大学, 医学部, 助教 (30750913)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 門脈塞栓術 / NBCA / 無水エタノール

Outline of Final Research Achievements

Portal vein of swine embolization was successfully performed using NLE (NBCA:lipiodol:ethanol=2:2:1). No NLE adherence to the balloon catheter was observed. The gelatin sponge + lipiodol mixture used as a control group flowed out from the portal vein, and another embolic material such as a coil for covering was also necessary. As another control group, NL (NBCA:lipiodol=1:2) stuck to the balloon catheter. Both 2:3:1 and 1:4:1 of NLI (NBCA:lipiodol:iopamidol) did not adhere to the balloon. NLE and NLI were considered to be useful embolic materials for portal vein embolization using a balloon catheter.

Free Research Field

放射線医学

Academic Significance and Societal Importance of the Research Achievements

NLE(NBCA:lipiodol:ethanol)もしくはNLI(NBCA:lipiodol:iopamidol)を用いてバルーンカテーテルをwedgeさせた状態でブタ門脈塞栓術を行うことに成功した。この結果、人体においてもNLE, NLIを用いた門脈塞栓術を行うことが可能と考えられる。安全に肝切除を行うための術前門脈塞栓術において、この2種類の塞栓物質を用いたさらなる研究が加速することが推察される。