Predicting the consistency of intracranial meningiomas using apparent diffusion coefficient maps derived from preoperative MRI

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17279
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Iwate Medical University
• Principal Investigator: Saura Hiroaki 岩手医科大学, 医学部, 助教 (30788716)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 拡散強調画像 / 髄膜腫

Outline of Final Research Achievements

The apparent diffusion coefficient (ADC) is derived from diffusion-weighted imaging (DWI) and is calculated using two optimized b values. The purpose of the present study was to determine whether preoperative standard and shifted ADC maps predict the consistency of intracranial meningiomas.　Standard and shifted ADC maps were　calculated using preoperative DWI in patients undergoing resection of intracranial meningiomas. Tumor　tissue located at the registered Regions of interest　(ROIs) was resected through craniotomy, and its stiffness was measured using a durometer.　For 76 ROIs obtained from 25 patients studied, significant negative correlations were observed between stiffness and the standard ADC (ρ = －0.465, p < 0.01) and the shifted ADC (ρ = －0.490, p < 0.01).
A combination of standard and shifted ADC maps derived from preoperative DWI can be used to predict the consistency of intracranial meningiomas.

Free Research Field

脳神経外科学

Academic Significance and Societal Importance of the Research Achievements

髄膜腫は原発性頭蓋内腫瘍の27.5％を占める最も頻度の高い脳腫瘍であり、脳神経外科の手術対象として頻度の高い疾患である。髄膜腫の硬さは、切除の難易度や手術合併症の発生率などに影響を与える重要な因子である。そのため、術前の画像検査で硬さがわかることによって手術の難易度をより高精度に予測し、安全な治療方針を患者さんに提示することが可能になると考えられる。