Development of radiolabeled probe for non-invasive detection of lipid radicals

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17283
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: Yamasaki Toshihide 神戸薬科大学, 薬学部, 助教 (60636710)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 脂質 / ラジカル / 放射性同位元素 / プローブ

Outline of Final Research Achievements

Lipid radicals are highly reactive species generated by lipid peroxidation, and are thought to be involved in various diseases such as atherosclerosis and cancer because they oxidize lipids and other biomolecules in a chain reaction, causing them to lose their original functions. Although fluorescent probes that capture lipid radicals generated in cells and tissues have been developed, there have been no probes that capture them non-invasively at the physiological level. In this study, we focused on nuclear medicine imaging, which allows highly sensitive imaging, and succeeded in developing an agent that captures lipid radicals generated in vivo. By obtaining spatiotemporal information on lipid radicals generated in individual organisms, it is expected to lead to the elucidation of the contribution and function of lipid peroxidation in oxidative stress diseases.

Free Research Field

放射化学

Academic Significance and Societal Importance of the Research Achievements

過酸化脂質は脂質代謝異常症やがんなど種々の疾患で増加していることが報告されており、生体内の過酸化脂質を測定することは健康状態の把握に有用である。本研究で開発された手法により、どのような場所で過酸化脂質が産生しているかを判別でき、過酸化脂質関連疾患の鑑別を可能とする診断法の開発に貢献できるものと期待している。