2023 Fiscal Year Annual Research Report
Maternal-neonatal transmission of extended-spectrum b-lactamase-producing enterobacteriaceae
| Project/Area Number |
19K17299
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| Research Institution | Shimane University |
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Principal Investigator |
平出 智裕 島根大学, 医学部, 特別協力研究員 (40638540)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | ESBL-producing E. coli / vertical transmission |
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| Outline of Annual Research Achievements |
In the final fiscal year, we statistically analyzed the data from the study and presented the results to the European Society of Pediatric Infectious Diseases.
This study aimed to determine whether extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBL-E) can be transmitted from the mother to the neonate.
This cross-sectional prospective study included 631 neonates and 629 expectant mothers. Among them, ESBL-E strains were isolated from 31 neonates (4.9%) and 25 pregnant women (4.0%). The ESBL-E transmission rates to the neonates were 32%, 45%, and 23% for the vertical, nosocomial, and household transmissions, respectively. Maternal carrier status and living with grandparents were associated with an increased risk of ESBL-E transmission to the neonates.
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