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2021 Fiscal Year Final Research Report

Comprehensive elucidation of intrahepatic biliary carcinogenesis induced by IDH mutations

Research Project

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Project/Area Number 19K17391
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionThe Institute for Adult Diseases Asahi Life Foundation

Principal Investigator

Fujiwara Hiroaki  公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行) (00814500)

Project Period (FY) 2019-04-01 – 2022-03-31
Keywords胆管癌 / 代謝 / エピゲノム
Outline of Final Research Achievements

By combining mutations in chromatin remodeling-related genes and abnormalities in the phosphatidylinositol 3-kinase pathway with IDH1 mutation, we succeeded in creating a multi-step carcinogenesis model from normal intrahepatic biliary epithelial cells to cholangiocarcinoma. As the next step, focusing on the histological differences between the IDH-wildtype models and IDH-mutant ones, we will plan to elucidate the molecular mechanism by several methods including comprehensive gene expression analysis.

Free Research Field

胆道疾患

Academic Significance and Societal Importance of the Research Achievements

近年、がん遺伝子パネル検査が保険適応なるなど、がん治療の個別化に向けた潮流は顕著になりつつある。基本的な戦略は各患者ごとに異なる癌固有の遺伝子変異に即した治療を行う、という方向性になるが、残念ながら現状ではそのような治療を享受することの出来る患者は1割程度と少ない。IDH変異は肝内胆管癌の約20%に存在する変異であるが、変異陽性癌に対する有効な治療法は目下確立されていない。本研究の成果により、その発癌に至るメカニズムを解明することが出来れば、IDH変異特異的に有効な治療法の開発へと繋げていくことが期待される。

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Published: 2023-01-30  

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