2022 Fiscal Year Final Research Report
Pathomechanisms of NAFLD and Sarcopenia: Exploring Therapeutic Target Molecules
Project/Area Number |
19K17418
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 53010:Gastroenterology-related
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Research Institution | Asahikawa Medical College |
Principal Investigator |
Hasebe Takumu 旭川医科大学, 医学部, 助教 (10596282)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | NAFLD |
Outline of Final Research Achievements |
The aim of this study was to investigate the correlation between hepatic and skeletal muscle pathological alterations in a mouse model of diet-induced non-alcoholic fatty liver disease (NAFLD). To examine the impact of age-related sarcopenia on skeletal muscle changes, both young and aged mice were included in the experiment. In the aged mice, the administration of a high-fat diet resulted in a diminished rate of muscle strength improvement over time. It was observed that the high-fat diet induced hepatitis in both the young and aged groups. However, the fibrosis associated with hepatitis was found to be unrelated to age. Notably, the aged mice exhibited pathological degeneration of muscle tissue due to the high-fat diet, indicating that the effects of obesity and fatty liver on muscle are more pronounced with advancing age.
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Free Research Field |
肝臓病学
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Academic Significance and Societal Importance of the Research Achievements |
本研究により肥満・脂肪肝においては年齢によらず肝線維化を来すが、筋肉の変化は高齢者において、より来しやすくなることが示唆された。NAFLDの病態進展は未解明な点が多いが、年齢によらず長期間NAFLDの病態を呈していることが肝線維化悪化に寄与していると考えられた。NAFLDと筋肉の分子生物学的連関は十分捉えられていないが、年齢や肥満・脂肪肝などが複合的に作用していることが示唆された。この成果により、NAFLD病態メカニズムの一部を明らかにできた。
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