Search for biomarkers of duodenal epithelial tumors by immunohistological/ molecular biological methods

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17423
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: The University of Tokyo
• Principal Investigator: Minatsuki Chihiro 東京大学, 医学部附属病院, 助教 (10800740)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 十二指腸上皮性腫瘍 / 免疫組織学 / 分子生物学

Outline of Final Research Achievements

Although duodenal tumors are relatively rare among gastrointestinal tumors, it has been increasing recently. We aimed to search for some markers that could be used as tumor markers in routine clinical practice and to discover genes that contribute to the onset and growth of tumors. As a result, it was found that the upregulation or downregulation of the expression of gastric type markers and gastrointestinal differentiation markers is associated with the malignancy of the duodenal epithelial tumors. In addition, using a technique of comprehensive gene expression analysis, we identified a group of genes that work in the tumor part by comparing the tumor and the non-tumor part.

Free Research Field

消化器病学

Academic Significance and Societal Importance of the Research Achievements

まれであるために十二指腸腫瘍の性質や悪性度の高さなどはよくわかっておらず、指針がないためにそういった病気を持つ方への対応にも難渋することがあったが、消化管腫瘍の中でもどのような傾向を持つ腫瘍であるかがわかれば治療薬の選択にも貢献することができ、また、腫瘍で働く遺伝子群を同定したため、その中から特に重要な遺伝子を絞ることができれば今後の治療方法の発展にも大きく貢献できる。