The regulation of the plasticity by long-term inflammation in intestinal stem cells

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17425
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Shuji Hibiya 東京医科歯科大学, 医学部附属病院, 特任助教 (20801963)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 炎症塑性 / 炎症性腸疾患

Outline of Final Research Achievements

The characteristic of inflammatory bowel disease (IBD) represented by ulcerative colitis and Crohn's disease is that relapse is repeated. Although inflammatory cell infiltration is not observed in the pathology after IBD remission, epithelial cell dysfunction such as crypt distortion and goblet cell depletion is observed, which suggests that it cannot be recovered by long-term inflammation. In this study, we have succeeded in delineating differences due to inflammation but not individual differences by comparing the same human cells before and after long-term inflammation. We identified an irreversible factor due to long-term inflammation and showed that targeting that factor restores some traits.

Free Research Field

消化器内科学

Academic Significance and Societal Importance of the Research Achievements

長期炎症による非可逆機構を初めて明らかとした。非可逆因子を標的とすることで、炎症塑性の一部可塑性変化を認め上形質の改善を認めたことから、再燃予防を見据えた新規炎症性腸疾患の治療薬開発が期待される。