Development of a non-invasive nucleic acid mutation detection technique for inflammatory bowel disease-associated neoplasia

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K17433
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Okayama University
• Principal Investigator: Kinugasa Hideaki 岡山大学, 大学病院, 助教 (70774800)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 炎症性腸疾患関連腫瘍 / リキッドバイオプシー / ctDNA / IBD関連腫瘍

Outline of Final Research Achievements

In this study, we developed a non-invasive nucleic acid mutation detection technique (liquid biopsy) as a new diagnostic method for inflammatory bowel disease (IBD)-associated neoplasia. We not only demonstrated the concordance between tumor tissue DNA and circulating tumor DNA (ctDNA), but also clarified the heterogeneous distribution of Fusobacterium in tumors and the origin and dynamics of ctDNA (half-life: 1.8-3.2 hours), thus clarifying the possibility of applying liquid biopsy in IBD-associated neoplasia.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

他の癌腫同様にIBD関連腫瘍を対象とした場合であってもctDNAをターゲットとしたリキッドバイオプシーは可能であり、非侵襲的な新たな手法の一つとなりうることを見出した。IBD関連腫瘍のブレークスルーとして、診断・モニタリング・治療などいずれにおいても可能性を秘めている。