Comparison of GLP-1-producing cells in duodenal mucosa and gastric emptying in FD patients with pancreatic enzyme abnormalities

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17444
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Nippon Medical School
• Principal Investigator: Hiroshi Yamawaki 日本医科大学, 医学部, 助教 (70720051)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 機能性ディスペプシア / 膵酵素異常 / 十二指腸炎

Outline of Final Research Achievements

We attempted to compare early gastric emptying, which is characteristic in patients with functional dyspepsia (FD), with duodenal mucosal inflammation and GLP-1-producing cell expression. Although no significant relationship has been found at present, we were able to clarify the relationship between anxiety and pancreatic exocrine dysfunction in FD patients with pancreatic enzyme abnormalities by collecting duodenal specimens from FD patients.
Using a new acid secretion inhibitor, vonoprazan, we compared activated eosinophils in the duodenal mucosa before and after treatment with FD patients.
We strongly expect that the study of inflammation and gastrointestinal hormones in the duodenum in FD will elucidate the pathogenesis of FD. Further studies are needed.

Free Research Field

機能性消化管障害

Academic Significance and Societal Importance of the Research Achievements

機能性ディスペプシア（FD）患者において特徴的である早期胃排出能と十二指腸粘膜内炎症細胞浸潤、GLP-1産生細胞の発現量との比較検討を試みた。その過程で、膵酵素異常を有するFD患者における心理的要素と外分泌膵機能の関連性を明らかにすることができた。また、膵酵素異常を伴うFD患者における脂肪摂取後の臨床的特徴に関して国際間の比較することができた。FDの病態解明の一助を担い、臨床的特徴に関しては新たな知見を加えることができたと確信している。