Analysis of pancreatitis-related TRP channel function

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17450
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Tohoku University
• Principal Investigator: Nakano Eriko 東北大学, 医学系研究科, 大学院非常勤講師 (90779729)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 慢性膵炎

Outline of Final Research Achievements

We established Trpv6 conditional knockout mouse. This mouse did not develop pancreatitis under normal condition, but administration of caerulein resulted in exacerbation of pancreatitis. We also identified new TRPV6 mutations in early-onset idiopathic pancreatitis. We constructed expression vectors of these mutants for future functional assay. We started to establish Trpv6 mutation knock-in mouse for further analysis.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

研究により得られた知見は、新規膵炎関連遺伝子による膵炎発症機序解明にむけて基盤となる重要なものである。作出したマウスモデルや変異体発現ベクター、ノックインマウス樹立により病態解明が進むと期待される。